关键词： 中西医结合   多囊卵巢综合症   排卵率   妊娠率  

摘要： 目的:探讨多囊卵巢综合症的中西医结合治疗方法。方法:选取2010年1月至2010年11月我院收治的94例多囊卵巢综合症患者,随机将其分为两组,即研究组和对照组。其中研究组应用中西医结合治疗联合指导同房;对照组应用常规西药联合指导同房治疗。研究两组排卵、妊娠率的差别。结果:中西医结合治疗排卵率、妊娠率明显高于单用西药的排卵率、妊娠率,且有统计学差异(P<0.05)。结论:中西医结合治疗多囊卵巢综合症可增加排卵率、妊娠率,优于单用西药治疗。

关键词： 闭源   多囊卵巢综合症   螺内酯   中药颗粒剂   达英-35   补血调经   中医药疗法  

摘要： 目的观察中药颗粒剂联合螺内酯治疗多囊卵巢综合征(PCOS)的临床疗效。方法将48例PCOS患者随机分为两组,对照组采用达英-35,治疗组采用中药颗粒剂(补血调经方)及螺内酯,疗程3个月(周期),停药3个月。观察性激素TE2、LH、FSH、月经、排卵、妊娠等变化并作统计分析。结果治疗组总有效率83.3%,显著高于对照组的54.1%,差异有统计学意义(P<0.05)。结论中药颗粒剂(补血调经方)联合螺内酯治疗多囊卵巢综合征的疗效显著,无不良反应。

关键词： 吡格列酮   克罗米酚   多囊卵巢综合症  

摘要： 目的:评价吡格列酮联合克罗米酚对多囊卵巢综合症(PCOS)患者的促排卵效果。方法:将68例PCOS患者随机分为观察组与对照组,每组各34例,观察组给予吡格列酮与克罗米酚进行治疗,对照组单用克罗米酚进行治疗,分别监测重组人绒促性素(HCG)注射日子宫内膜厚度、血清雌二醇(E2)、黄体生成素(LH)及睾酮(T)水平,并分别统计妊娠率。结果:观察组患者治疗后妊娠率为24.52%,显著高于对照组的16.42%,比较差异具有统计学意义(P<0.05)。结论:吡格列酮联合克罗米酚可促进P-COS患者排卵,提高妊娠率。

关键词： 来曲唑   促排卵   多囊卵巢综合征  

摘要： 目的探讨服用来曲唑(LE)两种不同天数对多囊卵巢综合征(PCOS)不孕症妇女的促排卵的效果。方法 96例促排卵的PCOS不孕症妇女,分为2组,A组56例:于月经周期第3～7天,每日口服来曲唑5mg,B组40例:于月经周期第3～9天,每日口服来曲唑5mg。周期第10天监测卵泡发育,若优势卵泡平均直径<11 mm,则加用HMG,从75 IU/d开始,肌肉注射,每2-3日监测1次卵泡,根据卵泡生长情况,逐渐加量,最大量用至150IU/d;当优势卵泡最大直径≥18 mm或尿LH阳性,肌肉注HCG5000-10 000 IU,诱发排卵,嘱患者于注射日或次日同房;或HCG注射后24h或36h行宫腔内人工授精(intrauterineinsemination,IUI)。比较两组患者的多种临床指标。结果 2组在促排卵治疗中,对两组HMG用量,卵泡成熟所需天数,HCG日子宫内膜厚度,差异有显著性P<0.01);在HCG日≥15mm卵泡个数,三线征阳性率,妊娠率,两组间差异无显著性(P>0.05);卵巢过度刺激综合征(OHSS),两组无统计学意义;两组均无卵泡未破黄素综合征(LUFS)发生。结论 5mg×7d方案,其在卵泡成熟天数,减少HMG用量方面均有优势。

关键词： 多囊卵巢综合征   氧化损伤和抗氧化修复   8-羟基脱氧鸟苷  

摘要： 多囊卵巢综合征(polycystic ovarian syndrome,PCOS)是育龄期常见的妇科内分泌疾病,发病机理尚不清楚,新的观点不断出现,已成为妇科内分泌学研究的热点和难点。PCOS可影响妇女从青春期-绝经后整个过程的身心健康.许多医学专家认为氧化损伤和抗氧化修复平衡参与许多疾病的发生、发展,甚至癌症的发生及发展。氧化损伤和抗氧化修复的重要因素如红细胞丙二醛和谷胱甘肽,染色体缺损、微核率和8-羟基脱氧鸟苷等与多囊卵巢综合症有着很大的关联,氧化损伤和抗氧化修复有可能为多囊卵巢综合症的病因探索、临床治疗提供新的突破。

关键词： 多囊卵巢综合症   促排卵药物   克罗米芬   疗效观察   临床   助孕   无排卵性不孕   抗雌激素作用  

摘要： 克罗米芬（CC）是第一个用于诱导排卵的药物,经口给药、安全、价格低廉等特点使CC明显优于其他需注射给药、价格昂贵的促排卵药物。克罗米酚（CC）利用其抗雌激素作用已成为治疗PCOS及无排卵性不孕的首选药。

关键词： polycystic ovary syndrome   adipose tissue   inflammatory markers   metabolic syndrome   overweight   TUMOR-NECROSIS-FACTOR   MIGRATION INHIBITORY FACTOR   TYPE-2 DIABETES-MELLITUS   LOW-GRADE INFLAMMATION   C-REACTIVE PROTEIN   INSULIN-RESISTANCE   HUMAN OBESITY   MACROPHAGE INFILTRATION   POSTMENOPAUSAL WOMEN   METABOLIC-DISORDERS  

摘要： Background: Previous studies have indicated that peripheral circulating markers of inflammation are elevated in women with polycystic ovary syndrome (PCOS), but thus far no studies concerning markers of inflammation in adipose tissue have been published. The aim of the study was to investigate whether patients with PCOS display increased expression of inflammatory markers in adipose tissue. Methods: Twenty overweight patients with PCOS, 10 lean patients with PCOS and 20 overweight controls had subcutaneous fat biopsies and blood samples taken. Adipose tissue levels of mRNA of inflammatory markers were determined by use of real-time PCR. Results: Overweight patients with PCOS had higher relative adipose tissue chemokine ligand 2 (P < 0.01), and its cognate receptor (P < 0.05), tumour necrosis factor-alpha (P < 0.001), interleukin (IL)-10 (P < 0.001) and IL-18 (P < 0.001) and the monocyte/ macrophage markers CD14 (P < 0.01) and CD163 (P < 0.01) mRNA levels compared with lean women with PCOS. There were no differences between overweight patients with PCOS and overweight control subjects in this respect. Within the PCOS group, markers of adipose tissue inflammation correlated significantly with obesity-related metabolic disturbances, but when data were adjusted for age and BMI, most correlations were lost. Conclusions: Overweight, rather than the PCOS diagnosis per se, appears to be the main explanatory variable for elevated adipose tissue inflammation in patients with PCOS.

关键词： polycystic ovary syndrome   anxiety   depression   quality of life   body image   QUALITY-OF-LIFE   MAJOR DEPRESSION   SELF-ESTEEM   BODY-IMAGE   WOMEN   PREVALENCE   POPULATION   ADOLESCENTS   DISORDERS   DISTRESS  

摘要： BACKGROUND: The impact of metabolic and reproductive features of polycystic ovary syndrome (P COS) compromises psychological functioning. We investigated factors associated with negative psychological functioning to determine whether they were predictive of anxiety and depression in PCOS. METHODS: A cross-sectional study was performed by questionnaire in 177 women with PCOS (mean +/- SD age 32.8 +/- 7.8 years) and 109 healthy controls (mean age 41.9 +/- 15.4 years). Main outcome measures were anxiety and depression, measured using the Hospital Anxiety Depression Scale (HADS) and Multidimensional Body-Self Relations Questionnaire (MBSRQ), respectively. RESULTS: Women with PCOS, compared with control women, had a higher mean anxiety HADS score (9.5 +/- 3.9 versus 6.5 +/- 3.6; P < 0.001), a higher mean depression score (5.7 +/- 3.7 versus 3.3 +/- 3.1; P < 0.001) and more negative body image in 7 out of 10 subscales of the MBSRQ. Multivariate regression analysis in PCOS showed that anxiety was predicted by self-worth (P < 0.0001), health evaluation (P = 0.005), time taken to diagnose PCOS (P = 0.003) and age (P = 0.02), while in control women, anxiety was predicted by self-worth (P = 0.009), health evaluation (P = 0.001) and rural living (P = 0.03). Depression in PCOS was predicted by self-worth (P = 0.0004), quality of life (QOL) (P = 0.004), fitness orientation (P = 0.002), appearance evaluation (P = 0.001) and time to diagnosis (P = 0.03) and in women without PCOS, by self-worth (P < 0.0001), QOL (P < 0.0001), illness orientation (P = 0.001) and appearance orientation (P = 0.02). CONCLUSIONS: Women with PCOS have increased anxiety, depression and negative body image compared with women without PCOS. In women with or without PCOS, body image and self-worth are predictors of both anxiety and depression, while QOL also predicts only depression. Time taken to diagnose PCOS is associated with poor psychological functioning.

关键词： polycystic ovary syndrome   visceral adiposity index   visceral obesity   oligomenorrhea   cardiometabolic risk   CORONARY-ARTERY-DISEASE   INSULIN-RESISTANCE   CARDIOVASCULAR RISK   ANDROGEN EXCESS   POSTMENOPAUSAL WOMEN   PREVALENCE   CRITERIA   OBESITY   HYPERANDROGENISM   MANAGEMENT  

摘要： Background: Women with polycystic ovary syndrome (PCOS) frequently exhibit central obesity, glucose intolerance, atherogenic dyslipidemia and hypertension, which are characteristic features of a condition of cardiometabolic risk. Our objective was to investigate the relationship between visceral adiposity index (VAI) and phenotypic characteristics in women with PCOS. Methods: We conducted a cross-sectional case-control study in our Endocrinology Outpatients Clinic. A total of 220 women with PCOS (Rotterdam definition) and 144 age-and BMI-matched healthy women were studied. We evaluated hyperandrogenemia and clinical hyperandrogenism, ovarian morphology, hypothalamic-hypophyseal axis and metabolic syndrome parameters. An oral glucose tolerance test (75 g glucose) measured areas under the curve (AUC) for insulin (AUC(2h-insulin)) and for glucose (AUC(2h-glucose)). Homeostasis model assessment of insulin resistance, the Matsuda index of insulin resistance and VAI were determined. Results: Of all the variables examined, at multivariate analysis, only AUC(2h-insulin) [odds ratio (OR): 1.00; 95% confidence interval (Cl): 1.00-1.00; P = 0.003] and VAI score (OR: 1.81; 95% Cl: 1.20-2.73; P = 0.005) showed an independent association with PCOS. All phenotypes with oligomenorrhea showed a higher VAI score than the control group (oligomenorrhea + hyperandrogenism: 2.49 +/- 1.46 versus 1.62 +/- 0.84, P < 0.001; oligomenorrhea + polycystic ovary morphology: 2.25 +/- 1.4 versus 1.62 +/- 0.84, P = 0.001; complete phenotype: 2.45 +/- 1.63 versus 1.62 +/- 0.84, P < 0.001). Conclusions: Our data suggest that VAI could be an easy and useful tool in daily clinical practice and in population studies for the assessment of cardiometabolic risk associated with PCOS.

关键词： Porphyrin   General Chemistry   Macrocycle   Oxidative Degradation   Porphin  

摘要： Influence of structure on the thermal properties of a large group of natural and synthetic porphyrins (H(2)P) and metalloporphyrins (MP) was analyzed on the ground of thermogravimetric studies. The initial stage of thermal degradation of "classical" porphyrin containing a flat or pseudo-planar macrocycle is a result of oxidative degradation of the macrocyclic structure with the formation of linear tetrapyrrols. The negative effect on the thermal stability of porphyrins exerts the violation of the planar structure of the macrocycle, and the presence of bulky alkyl and polar pseudoalkyl substituents. In many cases, the general trend in the decrease in the stability of metalloporphyrins (MP) in comparison with the corresponding H(2)P is a consequence of intramolecular metal <-> ligand redox processes.