关键词： 多囊卵巢综合症   二甲双胍   鹿胎膏   克罗米芬  

摘要： 目的：对比观察盐酸二甲双胍与盐酸二甲双胍、鹿胎膏联合治疗对多囊卵巢综合症临床疗效.方法：我院住院PCOS患者68人,按入院后确诊先后分为两组,分别接受盐酸二甲双胍单药治疗及盐酸二甲双胍、鹿胎膏联合治疗.治疗6个月后对比观察疗效.结果：中西医药物联合治疗组总有效率88.24%;单纯西医治疗组总有效率67.65%,差异性有统计学意义（P〈0.05）.结论：中西医药物联合合治疗多囊卵巢综合症疗效显著.

关键词： 肥胖型   多囊卵巢综合症   不孕   中西医结合  

摘要： 目的:观察分析中西医结合治疗肥胖型多囊卵巢综合症不孕的临床效果。方法:治肥胖型多囊卵巢综合症患者中随机选取60例,并分为观察组和对照组两组,每组30例。对照组患者予以基础的对症治疗,并口服达英-35和氯米芬;观察组患者在对照组的基础上加自拟中药方剂治疗,连续服用3个疗程直至妊娠。结果:经治疗后,两组的激素水平LH、LH/FSH、T值均出现明显降低(P<0.05)。综上,观察组治疗效果明显。结论:此治疗方法增加妊娠可能性,满足患者及家属的生育需求。

关键词： 腹腔镜卵巢打孔技术   临床效果   多囊卵巢综合症  

摘要： 目的探讨腹腔镜卵巢打孔技术治疗多囊卵巢综合症的安全性、有效性。方法将2006年1月-2009年12月期间入住本院的52例患有多囊卵巢综合征合并不孕不育患者作为观察对象。在患者全麻状态下,采用腹腔镜卵巢打孔技术进行临床治疗。术后观察患者性激素改变、自发或药物诱导排卵成功率、妊娠情况,并在2年内跟踪回访。结果患者采用腹腔镜卵巢打孔技术后,血清睾酮水平降低,LH/FSH值降低。术后部分患者排卵正常,月经恢复,自然妊娠。经后期回访,均无并发症产生。结论腹腔镜卵巢打孔技术治疗妇科疾病安全、合理、有效。

关键词： PCOS   fetal programming   hyperandrogenism   menstrual dysfunction   polycystic ovaries   INSULIN-RESISTANCE   PRECOCIOUS PUBARCHE   FETAL   HYPERANDROGENISM   PREVALENCE   GROWTH   WOMEN   FEATURES   SIZE   AGE  

摘要： The aetiology of polycystic ovary syndrome (PCOS) is unknown and contested. While it has been suggested that PCOS could have origins in perturbed development, epidemiological findings have been inconclusive. We aimed to examine potential fetal origins of PCOS. A retrospective birth cohort of 948 singleton female babies born at one hospital in South Australia in 19731975 was assembled. Birth characteristics were obtained from hospital records and PCOS symptoms were identified through interview and clinical examination when women were approximate to 30 years old. Based on the combination of PCOS symptoms, women formed seven outcome groups. A multinomial logistic regression analysis was used to investigate associations between birth characteristics and these outcome groups. After adjusting for gestational age, two distinct birth characteristics were associated with two PCOS symptom groups. Each 100 g increase in birthweight increased the risk of hyperandrogenism (as a single symptom) in adulthood by 5 [relative risk ratio: 1.05, 95 confidence interval (CI): 1.011.09]. In contrast, each one unit increase in the ponderal index at birth decreased the risk of all three key PCOS symptoms (hyperandrogenism, menstrual dysfunction and polycystic ovaries) by 21 (0.79, 95 CI: 0.660.93). These results suggest two discrete fetal programming pathways (related to high birthweight and to thinness at birth) are operating. Our findings point to differing aetiologies for symptom clusters, and inform the debate over symptoms that best represent the disorder.

关键词： 多囊卵巢综合症   性激素   月经失调   精神因素  

摘要： 目的 研究精神因素与卵巢多囊样改变(PCO)发病的关系.方法 取60例年龄在13～37岁临床表现为月经不调、闭经或月经过少,阴道或直肠B超均显示双侧卵巢多囊样改变,且同一个平面卵泡均大于10个,最大直径不超过10mm的妇女月经第2～5日或闭经妇女任意时间及月经规律B超示双恻卵巢正常的生育期妇女月经第2～5空腹静脉血3ml.离心取上清液并测出其性激素(FSH 、LH、TES、PRL )水平.通过对60例PCO患者的年龄、该年龄所处环境、性激素的比较及PCO患者与正常妇女性激素的比较.分析PCO患者的发病年龄、精神因素及性激素水平的特点.结果 患者发病年龄集中在20～30岁之间,占75%左右,13～19岁的占16.6%,>30岁仅占8.3%.发病率最高的年龄阶段为20～30岁,这一时期女性面对的外部环境刺激最多,压力很大.对60例PCO患者性激素的比较可见LH/FSH>1高达90%,可见高LH在卵巢多囊样改变中占很高比例.睾酮≥60ng者占58.3%,也占有很高的比例.PRL>25ng/ml 者占10%.而对照组妇女LH/FSH>1者占12%,LH/FSH≥2为零,睾酮≥60ng及PRL>25ng/ml者各占6%,符合PCOS诊断者为零.结论 18～30岁之间的妇女发病率最高,性激素表现也很典型.而这一时期的妇女压力最大,所应对的环境刺激最多,说明精神因素与PCO的发病有很大关系.

关键词： 多囊卵巢综合症   动物模型   雄激素  

摘要： 根据成人疾病发育起源的假说,早期发育中的不利影响会导致永久的生理和代谢改变,导致成年后疾病风险增长,建立了大鼠PCOS动物模型,为PCOS的发病机制及治疗方法的研究提供工具.实验采用方法为：将孕鼠分为雄激素组和正常对照组,每组5只,于孕鼠第10d起,雄激素组每天每只注射二氢睾酮1.2mg,对照组注射同体积的生理盐水,待2组仔鼠（正常组13只,二氢睾酮组16只）出生后生长至14~16周,处死,取卵巢观察2组仔鼠卵巢形态,取静脉血测血性激素变化、空腹血糖、胰岛素水平及血脂变化.研究结果表明：雄激素组仔鼠卵巢囊性改变、高雄激素血症、血糖增高以及性周期不规则,与人的多囊卵巢综合症部分特征相似.

关键词： 热带地区   湿热质   多囊卵巢综合症   预防治疗  

摘要： 湿热体质是妇女的常见体质类型,热带地区湿热体质与妇科疑难病多囊卵巢综合征的发病关系密切,针对热带地区本病高危人群的体质特点及时进行全面调整可降低该疾病的发生率,从而探讨预防治疗多囊卵巢综合症之重要意义。

关键词： 二甲双胍   罗格列酮   多囊卵巢综合症   非酒精性脂肪性肝病  

摘要： 目的:评价罗格列酮联合二甲双胍治疗多囊卵巢综合症(PCOC)合并非酒精性脂肪性肝病(NAFLD)的疗效。方法:将编号为FTWS007课题样本中体检确诊为多囊卵巢综合症合并非酒精性脂肪性肝病患者47例,接受6个月罗格列酮联合二甲双胍治疗。在用药3个月后和6个月后分别检测卵巢体积、BMI、血清LH/FSH、Homa-IR、T、TG、ALT、AST、GGT水平,与服药前诊断指标进行两两比较。结果:上述指标水平均有明显下降,差别有统计学意义(P<0.05)。对NAFLD影像结论进行累加Logit回归分析,显示轻度NAFLD的疗效比中度NAFLD的疗效好(OR=5.55,P=0.00),服药6个月的疗效比服药3个月的好(OR=8.79,P=0.00)。结论:罗格列酮联合二甲双胍治疗多囊卵巢综合症合并非酒精性脂肪性肝病安全有效,提示多囊卵巢综合症并发非酒精性脂肪性肝病患者应尽早进行长时间的干预治疗。

关键词： 补肾活络方   多囊卵巢综合症   IGF-2形态学   动物模型   实验研究  

摘要： 目的:探讨补肾活络方对促进肾虚血瘀型不孕症大鼠卵泡发育及促排卵的可能机制。方法:建立PCOS大鼠不孕模型,光镜下连续观察阴道脱落细胞涂片1个性周期,观察动情周期变化及排卵率,并运用免疫组化和显微形态学等技术,对正常组、模型组、中药组、西药组SD雌性大鼠卵巢细胞IGF-2基因表达水平进行检测。结果:中药组、西药组与模型组在动情周期变化及排卵率比较差异有统计学意义(P<0.05);中药组、西药组与正常组在动情周期变化比较差异无统计学意义(P>0.05);中药组与西药组动情周期变化及排卵率比较差异无统计学意义(P>0.05);模型组IGF-2的表达强度上都不及正常组、中药组和西药组(P<0.05);中药组与正常组IGF-2表达强度比较无差异(P>0.05);中药组与西药组IGF-2比较有差异(P<0.05)。结论:中药补肾活络方能诱导PCOS大鼠的动情周期,增加PCOS大鼠排卵率。

关键词： Dyslipidemic   Metabolic Syndrome   Prevalence   Polycystic Ovarian Syndrome   DENSITY-LIPOPROTEIN CHOLESTEROL   FOLLOW-UP   DISEASE  

摘要： Background: Polycystic ovarian syndrome (PCOS) is a condition associated with chronic anovulation, insulin resistance and androgen excess. Women with this syndrome are at increased risk of metabolic syndrome. Objective: The aim of the present study was to determine the prevalence of metabolic syndrome (MBS) in women with PCOS referred to Arash Hospital in different ages and body mass index (BMI). Materials and Methods: A cross-sectional study was conducted in Gynecologic Clinic at Arash Hospital affiliated with Tehran University. A total of 282 women with PCOS ages between 15-40 years were included. The prevalence of Metabolic Syndrome and its components in this population were the main outcomes. Height, weight, waist circumference, blood pressure and laboratory tests (FBS, TSH, HDL-C, serum prolactin, triglycerides and total cholesterol) were measured in this population. Results: The prevalence of MBS in PCOS women was 22.7% (64 cases). The rate of central obesity, FBS more than 110 mg/dl, triglycerides more than 150 mg/dl, high-density lipoprotein cholesterol levels (HDL-C) less than 50 mg/dl, and blood pressure >= 130/85 mmHg in PCOS women was 31% (87), 3.2% (9), 33% (93), 68.8% (194), and 10.6% (30), respectively. The risk of MBS was increased in older and the obese women (BM I >= 30 kg/m(2)). Conclusion: The present sample showed women with PCOS have a high prevalence of MBS and its individual components, particularly decreased HDL-C.