关键词： 经阴道彩色多普勒超声   多囊卵巢综合症  

摘要： 目的 :探讨经阴道彩色多普勒超声在多囊卵巢综合征 (PCOS)诊断中的价值。方法 :对 3 6例多囊卵巢综合征患者的卵巢进行探查 ,观察其结构改变特点、彩色血流显像特征以及血流参数的变化。结果 :与正常组比较 ,PCOS组卵巢内呈充血状血流波型为低阻抗型。血流参数与正常组对比有显著性差异 (P<0 .0 5)。结论 :经阴道彩色多普勒超声可明显提高 PCOS的诊断水平

关键词： 海归派   南京总医院   消化道肿瘤   中国留学生   幻灯片   精神家园   妇产科学习   急性肺损伤   多囊卵巢综合症   消化系统疾病  

摘要： 自20世纪90年代初开始,南京军区南京总医院一批批留学海外的学子纷纷回到医院,在各自的岗位上奉献着自己的才华。他们中有被江泽民主席授予一等功的肾脏病专家刘志红,在国内外知名的病理学专家周晓军、心胸外科专家景华、麻醉科专家徐建国、药理学专家李金恒等等。21世纪初年,又一批年轻学子归来,给璀璨的星空又增添了几颗耀眼的新星。

关键词： IMPAIRED GLUCOSE-TOLERANCE   INDEPENDENT RISK FACTOR   INSULIN-RESISTANCE   PREMATURE PUBARCHE   CARDIOVASCULAR RISK   FACTOR-VII   MYOCARDIAL-INFARCTION   BINDING PROTEIN-1   DIABETIC-PATIENTS   PLASMA-LEVELS  

摘要： In both obese and nonobese women, polycystic ovary syndrome (PCOS) is essentially a disorder of hyperinsulinemic insulin resistance, and it may be heralded by precocious pubarche (PP; appearance of pubic hair in girls aged <8 y). The risk of progression from PP to PCOS is related to low birth weight, but there are no early biochemical markers of this risk. As increased plasminogen activator-inhibitor type 1 (PAI-1) activity (act) is an early marker of cardiovascular risk in PCOS. we have sought abnormalities in young girls with PP. In 33 young PP girls (age range 6-11 y), PAI-1-act was increased (mean + SEM: 15.6 +/- 1.5 IU/mL) compared with age-, sex-, and pubertal stage-matched controls (n = 13, 10.7 +/- 1.9. p < 0.05). PAI-1-act levels were inversely related to birth weight SD score (r = -0.33,p < 0.05), and PAI-1-act levels were therefore higher in PP girls with low birth weights (n = 14, 19.5 +/- 2.5 IU/mL) than normal birth weights (n = 19, 12.8 +/- 1.5, p < 0.01). During longitudinal observation in 10 PP girls (mean time interval 2.7 y), PAI-1-act levels in early puberty were positively related to postmenarcheal insulin levels (mean serum insulin SDS postoral glucose, r = 0.65, p < 0.05), and showed a similar relationship to postmenarcheal testosterone levels (r = 0.61, p = 0.06). Together with low birth weight, increased plasma PAI-1-act levels in early pubertal PP girls may indicate those girls with greater risk of developing hyperinsulinemic-hyperandrogenism features of PCOS.

关键词： 多囊卵巢综合症   垂体腺   男性激素   临床研究   代谢失调   排卵感应   综合病症  

摘要： 虽然内分泌性高血压(表1)确切的患病率尚不清楚，但几乎可以肯定其患病率低于高血压病例总数的5％。对本病保持高度警觉并进行适当的调查研究对做出诊断是十分必要的。内分泌性高血压患者容易死于脑血管疾病，但这种情况通常是可以逆转的，认识到这一点很重要。

关键词： 多囊卵巢综合症   血管内皮生长因子   胰岛素  

摘要： 目的：通过对PCOS患者血浆、卵泡液VEGD水平的测定,血清胰岛素水平的测定,对VEGF与PCOS的关系进行探讨,同时对VEGF与胰岛素水平的关系进行探讨.结论：VEGF在卵巢功能的维持及调节血管通透性方面起重要作用.该研究中PCOS患者的血浆及卵泡液VEGF水平均较对照组高,提示VEGF在PCOS患者中的高表达,是PCOS患者卵巢间质血管化增加的基础.而VEGF与胰岛素水平无明显的相关关系.

关键词： 半胱氨酸/代谢   多囊卵巢综合征/药物疗法   多囊卵巢综合征/代谢   二甲双胍/治疗应用   综合征   甾醇类/代谢   女(雌)性   人类  

关键词： OBESE WOMEN   IMPROVEMENT  

摘要： Polycystic ovary syndrome is now acknowledged by many to be the most common endocrine disorder among women of reproductive age and the major cause of anovulatory infertility. This has led to a concern about the effect of polycystic ovary syndrome on long-term health, particularly with regard to diabetes and coronary heart disease.

关键词： 多囊卵巢综合征   排卵障碍   电针治疗   疗效  

摘要： 多囊卵巢综合症是育龄妇女最常见的内分泌紊乱性疾病,其发病率占女性人口的5～6%,占无排卵性不孕病因的50～70%,其临床表现多样,主要是由于持续性无排卵和雄激素过多引起,其中与其它原因所致的排卵障碍相比,卵巢综合症的排卵障碍和妊娠率较低,我院自1997年5月至2001年5月起开始采用电针治疗多囊卵巢综合症患者30例,现报导如下:

关键词： 妈富隆   多囊卵巢综合症   促排卵   疗效研究   PCOS   避孕药  

摘要： 多囊卵巢综合征(PCOS)是引起育龄妇女月经紊乱的常见病因之一,临床表现为排卵障碍,妈富隆为口服短效避孕药,作为对PCOS患者诱发排卵治疗的前期治疗有一定的疗效,现报告如下.

关键词： RECEPTOR SUBSTRATE-2   GENE   PATHOGENESIS   POLYMORPHISM   MUTATIONS   SECRETION   PROMOTER   SYSTEM  

摘要： To assess the role of insulin receptor, insulin receptor substrate (IRS)-1, and IRS-2 genes in insulin resistance, we explored the genomic DNA in women with polycystic ovary syndrome (PCOS) and a variable degree (mean +/- SE) of insulin resistance (homeostasis model assessment index for insulin resistance [HOMA(IR)] 3.2 +/- 0.6, n = 53; control subjects 1.56 +/- 0.34, n = 102) using direct sequencing. Whereas no novel mutations were found in these genes, gene-dosage effects were found on fasting insulin for the Gly972Arg IRS-1 variant and on 2-h plasma glucose for the GIy1057Asp IRS-2 variant. The Gly972Arg IRS-1 variant was more prevalent in insulin-resistant patients compared with non-insulin-resistant individuals or control subjects (39.3 vs. 4.0 and 16.6%, P < 0.0031, respectively). A multivariate model that included BMI as a variable revealed significant effects of the Gly1057Asp IRS-2 variant on insulin resistance (P < 0.016, odds ratio [OR] 7.2, 95% CI 1.29-43.3). HOMA(IR) was higher in carriers of both IRS variants than in those with IRS-2 mutations only or those with wild-type variants (6.2 +/- 2.3, 2.8 +/- 0.5, and 1.8 +/- 0.2, respectively; P < 0.01), and it was significantly associated with this genotype (P < 0.0085, OR 1.7, 95% CI 1.09-2.99). We conclude that polymorphic alleles of both IRS-1 and IRS-2, alone or in combination, may have a functional impact on the insulin-resistant component of PCOS.