关键词： 卵巢过度刺激综合症   误诊误治   人绒毛膜促性腺激素   多囊卵巢综合症   妊娠   宫内   病例摘要   不能平卧  

摘要： 1病例摘要患者30岁,因绒毛膜促性腺激素促排卵后15 d,腹胀10d,加重伴尿少2 d于2006.7.13拟'重度卵巢过度刺激综合症(OHSS)'收入院.既往月经欠规则,Lmp:2006-6-16.结婚5年,无避孕,G0P0A0.患有多囊卵巢综合症(PCOS).本周期用HMG+HCG促排卵.

关键词： insulin resistance   molecular genetics   oxidative stress   polymorphism   premenopausal women   INSULIN-RESISTANCE   CARDIOVASCULAR-DISEASE   OXIDATIVE STRESS   GENE   GLUCOSE   HOMEOSTASIS   HYPOTHESIS   HIRSUTISM   GENOTYPE  

摘要： BACKGROUND: Because serum paraoxonase activity is influenced by the -108C/T polymorphism in the PON1 gene, we studied its involvement in the decreased paraoxonase activity recently described in the polycystic ovary syndrome (PCOS). METHODS: Paraoxonase activity, PON1-108C/T genotypes and clinical, hormonal and biochemical variables were evaluated in a case-control study involving 139 consecutive PCOS patients and 85 healthy controls matched for BMI and prevalence of smoking. RESULTS: Women homozygous for -108T presented with reduced serum paraoxonase activity compared with carriers of C alleles (P < 0.001), both in PCOS patients and in controls. Although homozygosity for T alleles was more prevalent in PCOS patients than in controls (P = 0.003), serum paraoxonase activity was not significantly different in the PCOS and control groups. In a stepwise multivariate linear regression model, homozygosity for PON1-108T alleles was the only significant predictor of the logarithm of serum paraoxonase activity (beta = -0.328, t = -4.176, P < 0.001). CONCLUSIONS: In premenopausal women from the Spanish population, the PON1-108C/T polymorphism, and not PCOS, is an important determinant of serum paraoxonase activity.

关键词： QUALITY-OF-LIFE   METABOLIC SYNDROME   INSULIN-RESISTANCE   GLUCOSE-TOLERANCE   THECA CELLS   TESTOSTERONE   HEALTH   HOMEOSTASIS   HIRSUTISM  

摘要： Background: Surprisingly, the prevalence of polycystic ovary syndrome ( PCOS) in otherwise unselected overweight or obese women is unknown, despite obesity being frequent in patients with PCOS. We conducted the present study to obtain an unbiased estimate of the prevalence of PCOS in unselected overweight and obese premenopausal women from Spain. Methods: All premenopausal women reporting to the Department of Endocrinology, Hospital Universitario Ramon y Cajal, for dietary treatment of overweight or obesity from May 2002 to December 2005 were prospectively recruited. Women referred for any other reason were automatically excluded to avoid selection bias. Diagnosis of PCOS relied on the presence of clinical and/or biochemical hyperandrogenism, oligo-ovulation, and exclusion of secondary causes. Anthropometric measurements, hirsutism scores, and androgen, gonadotropin, metabolic, and lipid profiles were obtained. Results: Of a total of 113 consecutive women recruited, 32 (28.3%) were diagnosed as having PCOS (95% confidence interval, 20.0%-36.6%). The prevalence of PCOS was not different when considering the degree of obesity. Another 3 women presented with hyperandrogenemia without oligo-ovulation, 2 had idiopathic hirsutism, 2 had chronic oligomenorrhea without clinical or biochemical hyperandrogenism, and 2 had oligomenorrhea with hyperprolactinemia, precluding the diagnosis of PCOS. The remaining 72 women (63.7%) had no evidence of hyperandrogenism or reproductive abnormalities. Conclusions: Our results demonstrate a 28.3% prevalence of PCOS in overweight and obese women from Spain, which is markedly increased compared with the 5.5% prevalence of PCOS in lean women of our country. Therefore, PCOS must be routinely ruled out in overweight and obese premenopausal women seeking advice for weight loss.

关键词： 多囊卵巢   腹腔镜   不孕症  

摘要： 目的评价腹腔镜下卵巢打孔术对多囊卵巢综合征(PCOS)所致不孕症的疗效。方法在腹腔镜下对PCOS患者的卵巢进行多点电凝打孔术,比较手术前后血卵泡刺激素(FSH),黄体生成素(LH)和雄激素(T)值的变化及月经情况的改变,观测术后排卵情况、妊娠情况,并与常规药物治疗及开腹手术治疗进行比较。结果排卵率为90.0%(27/30),妊娠率达76.7%(23/30)。术后LH和T值明显下降,差异有显著性(P<0.01)。结论腹腔镜下卵巢多点电凝打孔术不仅具有较高的治愈率,而且手术操作简单安全、并发症少、术后粘连少,是治疗PCOS致不孕患者的一种有效方法。

关键词： IMPAIRED GLUCOSE-TOLERANCE   MEDICAL PROGRESS   PREGNANCY   RISK   HISTORY   TIME  

摘要： The article presents a study that examines the prevalence and association of polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM) among a large multiethnic population of pregnant women in northern California. The study reveals that pregnant women with diagnosed PCOS have a more than twofold increased odds of GDM compared with women without PCOS or symptoms.

关键词： 抗苗勒管激素   卵巢功能   卵巢储备   卵巢反应性   多囊卵巢综合症  

摘要： 抗苗勒管激素是转化生长因子-β家族成员之一,其在雄性胎儿的发育过程中引起苗勒氏管的退化。在雌性,抗苗勒管激素主要由卵巢窦前卵泡和小窦卵泡颗粒细胞分泌,与卵巢功能密切相关,是最新发现的评价卵巢年龄的重要指标,可很好地预测卵巢对促排卵药物的反应性,并和女性生殖内分泌疾病多囊卵巢综合征的发病与临床特征相关。

关键词： 排卵障碍性不孕   中西医结合治疗   多囊卵巢综合症   不孕症诊断   原发性不孕   继发性不孕   继发性闭经   临床资料   育龄妇女   体温测定  

摘要： 笔者从1998—02—2001—10，用中西医结合治疗排卵障碍不孕80例，疗效满意。 现报告如下。 1临床资料 80例病例均系育龄妇女因不孕而就诊，符合不孕症诊断标准，行输卵管碘油造形证实输卵管完全通畅，连续3个月基础体温测定成单相性，B超监测无成熟卵泡及排卵征象。80例病例中，原发性不孕46例，继发性不孕34例，年龄最小21岁，最大36岁，月经不调60例，继发性闭经8例，多囊卵巢综合症12例，病程最短者1a，最长者6a。

关键词： 多囊卵巢综合症   血管紧张素-Ⅱ   白介素-6   胰岛素样生长因子-1  

摘要： 探讨促排卵治疗对多囊卵巢综合症(PCOS)患者血管活性因子血管紧张素-Ⅱ(AT-Ⅱ)、白介素-6(IL-6)、胰岛素样生长因子-1(IGF-1)的影响.21例PCOS患者与8例正常女性在自然或人工月经周期的第2 d卵泡期进行绒毛膜促性腺激素(HCG)促排卵,于试验前及试验后3、6、12、18、24 h静脉取血,放免法测定血清AT-ⅡI、L-6I、GF-1浓度.HCG刺激后PCOS组的血清AI-Ⅱ水平在各取血时点均升高,但只有3 h取血点是显著升高(P<0.05).PCOS组HCG刺激后各时点的血清AI-Ⅱ水平均高于对照组,也只有3 h取血点是显著高于对照组.血清IL-6及IGF-1水平在试验前后各时间点间差异均无显著性.结果提示HCG刺激促进PCOS患者外周血AT-Ⅱ水平升高.

关键词： 多囊卵巢综合症   不孕症   腹腔镜   卵巢打孔  

摘要： 目的探讨应用腹腔镜治疗耐克罗米酚多囊卵巢综合症合并不孕症的疗效、方法。方法分析30例耐克罗米酚的多囊卵巢综合症合并不孕的临床资料,观察采用腹腔镜手术治疗耐克罗米酚的多囊卵巢综合症合并不孕的疗效。结果该组病人术后月经情况均有明显改善,排卵率83.3%,妊娠率46.7%,妊娠后流产率14.3%。结论腹腔镜手术是目前治疗耐克罗米酚的多囊卵巢综合症合并不孕症患者有效快捷的治疗方法。

关键词： IDENTIFICATION   IOL   OPERON   PHAGE  

摘要： D-chiro-Inositol (DCI) is a drug candidate for the treatment of type 2 diabetes and polycystic ovary syndrome, since it improves the efficiency with which the body uses insulin and also promotes ovulation. Here, we report genetic modification of Bacillus subtilis for production of DCI from myo-inositol (MI). The B. subtilis iolABC-DEFGHIJ operon encodes enzymes for the multiple steps of the MI catabolic pathway. In the first and second steps, MI is converted to 2-keto-MI (2KMI) by IoIG and then to 3(D)-(3,5/4)-trihydroxycyclohexane-1,2-dione by IoIE. In this study, we identified ioll encoding inosose isomerase, which converts 2KMI to 1-keto-(D)-chiro-inositol (1KDCI), and found that IoIG reduces 1KDCI to DCI. Inactivation of iolE in a mutant constitutively expressing the iol operon blocked the MI catabolic pathway to accumulate 2KMI, which was converted to DCI via the activity of loll and IoIG. The mutant was able to convert at least 6% of input MI in the culture medium to DCI.