关键词： hyperandrogenism   insulin resistance   polycystic ovary syndrome   visfatin   GESTATIONAL DIABETES-MELLITUS   ADIPOSE-TISSUE   SKELETAL-MUSCLE   PLASMA   SENSITIVITY   HUMANS   EXPRESSION   ALPHA   FAT  

摘要： BACKGROUND: Visfatin, a protein secreted by adipose tissue, is suggested to play a role in pathogenesis of insulin resistance. In polycystic ovary syndrome (PCOS), insulin resistance might be involved in the development of endocrine and metabolic abnormalities. The aim of the study was to asses the relation between serum visfatin concentration and insulin sensitivity and markers of hyperandrogenism in lean and obese PCOS patients. METHODS: The study group consisted of 70 women with PCOS (23 lean and 47 obese) and 45 healthy women (25 lean and 20 obese). Euglycemic hyperinsulinemic clamp and the measurements of serum visfatin, sex hormones were performed. RESULTS: The PCOS group had lower insulin sensitivity (P = 0.00049) and higher serum visfatin (P = 0.047) in comparison to the control group. The decrease in insulin sensitivity was present in both the lean (P = 0.019) and obese (P = 0.0077) PCOS subjects, whereas increase in serum visfatin was observed only in lean PCOS subjects (P = 0.012). In the whole group, serum visfatin was negatively correlated with insulin sensitivity (r = -0.27, P = 0.004). This relationship was also observed in the subgroup of lean (r = -0.30, P = 0.038), but not obese women. Additionally, in lean women, visfatin was associated with serum testosterone (r = 0.47, P = 0.002) and free androgen index (r = 0.48, P = 0.002), independently of other potential confounding factors. CONCLUSIONS: Visfatin is associated with insulin resistance and markers of hyperandrogenism in lean PCOS patients.

关键词： 多囊卵巢综合症   诊断方法   治疗方法   临床分析  

摘要： In order to improve the treatment outcome and facilitate the clinical practice,a diagnostic classification of heterogeneous disease-polycystic ovary syndrome(PCOS)is *** is classified into 2 main types(Ⅰ,Ⅱ)and 4 subtypes(Ⅰa,Ⅰb,Ⅱa,Ⅱb):PCOSⅠrefers to cases with hyperandrogenemia derived from the ovary(Ⅰa)or from both the ovary and the adrenal cortex(Ⅰb).PCOS Ⅱ refers to cases with both hyperandrogenemia and hyperinsulinemia,while Ⅱb being severer than Ⅱa,like *** efficacy of integrative medicine treatment on this classification is mentioned.

关键词： 高雄激素血症   PCOS   SOCS-3   瘦素抵抗   多囊卵巢综合症   无排卵性月经   内分泌疾病   专题学术研讨会  

摘要： 多囊卵巢综合症(PCOS)是育龄妇女中最常见的内分泌疾病,全球范围内5%～10%育龄妇女受此病困扰,以无排卵性月经、不孕、高雄激素血症和胰岛素抵抗为特征.在2003年鹿特丹[1]PCOS专题学术研讨会上,将PCOS的诊断定为:①稀发排卵或无排卵.②高雄激素血症的临床和生化特征(排除其他引起雄激素升高疾病,比如肾上腺皮质增生、分泌雄激素肿瘤或柯兴式综合症).③B超表现为卵巢内多卵泡发育,每切面10个以上.上述3个标准中符合2个则可诊断为PCOS.

关键词： 多囊卵巢综合症   心血管疾病   胰岛素抵抗   动脉粥样硬化  

摘要： 多囊卵巢综合症(Polycystic ovary syndfome,PCOS)是一种育龄期妇女常见病,临床上常伴有月经稀少、不孕、多毛和肥胖等症状,双侧卵巢呈囊性增大,女性内分泌出现紊乱,PCOS中有50%妇女表现为肥胖,尽管多数妇女以不孕和月经异常就诊,但有研究表明PCOS患者的远期并发症如心血管疾病的发生率远远高于正常人群。本文主要探讨了PCOS与心血管疾病的相关性。

关键词： 多囊卵巢综合症   血管内皮生长因子   胰岛素  

摘要： 目的:通过对PCOS患者血浆、卵泡液VEGD水平的测定,血清胰岛素水平的测定,对VEGF与PCOS的关系进行探讨,同时对VEGF与胰岛素水平的关系进行探讨。方法:采用病历-对照的方法对PCOS患者及健康对照妇女进行血浆及卵泡液VEGF水平进行测定与比较,同时对PCOS患者的血清胰岛素水平进行测定,比较其与VEGF的关系。结果:两组的血浆VEGF水平分别为179.01±155.97pg/mL,87.49±7.18pg/mL,两组的卵泡液VEGF浓度为524.82±273.68pg/mL,243.66±162.19pg/mL,P值均<0.05,PCOS患者血浆和卵泡液VEGF水平与对照组有显著性差异,PCOS组血浆和卵泡液VEGF水平比对照组高。血清几个时点的胰岛素水平及曲线下面积与血浆VEGF水平均无相关关系。结论:VEGF在卵巢功能的维持及调节血管通透性方面起重要作用。本研究中PCOS患者的血浆及卵泡液VEGF水平均较对照组高,提示VEGF在PCOS患者中的高表达,是PCOS患者卵巢间质血管化增加的基础。而VEGF与胰岛素水平无明显的相关关系。

关键词： TYPE-2 DIABETES-MELLITUS   INSULIN-RESISTANCE   LUTEINIZING-HORMONE   NONOBESE PATIENTS   LIFE-STYLE   PREVALENCE   RISK   TOLERANCE   STIMULATION   PREDICTORS  

摘要： Background: The Canadian and American Diabetes Associations recommend the use of an oral glucose tolerance test to screen for abnormal glucose tolerance among women with polycystic ovary syndrome when their fasting plasma glucose level is 5.7 mmol/L or more (Canadian guideline) and 5.6 mmol/L or more (American). Our objective was to determine the predictive value of 5.6 mmol/L as a fasting plasma glucose cutoff for detecting abnormal glucose tolerance in women with polycystic ovary syndrome, and then to define the optimal cutoff for this population. Methods: An oral glucose tolerance test was administered to 105 consecutive women with polycystic ovary syndrome referred to an academic reproductive endocrine clinic. We calculated sensitivity, specificity and likelihood ratios. Results: The sensitivity of a 5.6 mmol/L cutoff was 48% (95% confidence interval [CI] 30%-67%); its specificity, 98.7% (95% CI 96.1%-100%). With this cutoff, 52% of women with polycystic ovary syndrome whose glucose tolerance is abnormal would be missed. The prevalence of abnormal glucose tolerance was 28%, with a positive predictive value of 93% (95% CI 81%-100%) and a negative predictive value of 83% (95% CI 76%-91%). The likelihood ratio for a positive test was 36.7 (95% CI 5.0-267), and for a negative test, 0.5 (95% CI 0.4-0.7). The optimal fasting plasma glucose cutoff value was 5.0 mmol/ L, with a 79% sensitivity (95% CI 65%-94%) and 66% specificity (95% CI 55%-77%). If this cutoff were used, 24% of women with abnormal glucose tolerance would still be missed. Interpretation: The Canadian and American recommendations - of screening for abnormal glucose tolerance with an oral glucose tolerance test only when the results of a fasting plasma glucose test are 5.7 mmol/L (or 5.6 mmol/L) or more - are inappropriate for women with polycystic ovary syndrome. We therefore recommend that all women with polycystic ovary syndrome have an oral glucose tolerance test.

关键词： 多囊卵巢综合症   临床特点   诊治   内分泌疾病   雄激素过多   胰岛素抵抗   内分泌原因   2型糖尿病  

摘要： 多囊卵巢综合症（PCOS）是一种常见的妇科内分泌疾病，发病率为5％～10％，以雄激素过多、胰岛素抵抗和无排卯为主要临床特征，但其生理及临床表现有高度的多样性、异质性。PCOS多起病于青春期初潮后，是女性无排卯性不孕症最常见的内分泌原因，也是代谢综合征和2型糖尿病的主要危险因素，可增加女性患心血管疾病的风险。此外，不孕症、多毛及痤疮等症状可明显加重患者的社会及心理负担。因此，对可疑病例进行筛查，并在发病早期即开始治疗，

关键词： 多囊卵巢综合症   不孕   中西医结合治疗   疏肝补肾   活血化瘀  

摘要： [目的]观察中西医结合治疗多囊卵巢导致不孕的临床疗效。[方法]将76例病例分为两组,治疗组56例用氯米芬胶囊、乙烯雌酚、HCG等西药,遵循中医“肾主生殖”的理论,按照女子月经周期中卵泡生长、发育、排出的不同生理阶段,用不同作用的中药;对照组20例,单纯用上述西药治疗。观察两组的妊娠率。[结果]6个月以后统计,治疗组妊娠率60·6%,对照组妊娠率30%,两组对照差异有显著性(P<0·05?。[结论]中西医结合治疗多囊卵巢导致的不孕有良好的疗效。

关键词： CLOMIPHENE CITRATE INDUCTION   CLINICAL-TRIAL   DOUBLE-BLIND   OVULATION   METFORMIN   INFERTILITY   WOMEN  

摘要： Of the estimated 6.7 million women with fertility problems in the United States, 35% have received drugs to induce ovulation.1 The most common cause of anovulation among infertile women is the polycystic ovary syndrome, a condition typically characterized by irregular menses, androgen excess, and polycystic-appearing ovaries. The condition is associated with insulin resistance and *** a number of drugs have been used to induce ovulation in women with the polycystic ovary syndrome, clomiphene citrate is a simple, tried-and-true treatment. Clomiphene is an orally active, antiestrogenic substance that promotes the release of follicle-stimulating hormone from the pituitary gland, thus stimulating . . .

关键词： 体毛   春性   请看   隐私部位   多囊卵巢综合症   乳房发育   分泌过多   就这样   性腺功能   多毛症  

摘要： 开栏语:去年,你看了"门诊的亮光"从今年第一期你开始"身体阅读",首先,恭请你昕听"花开的声音"。"花开的声音"静悄悄、羞答答,这样的青葱岁月,有生长的隐痛,也有莫名的激动,更有初涉爱河的甜蜜。这个栏目,我们力求青春性、系列性、专题性、实用性、权威性,不仅关注你的各种难言的隐私病,也让你了解年轻身体的其他秘密青春的冲动和身体的养护。总之,是你年轻身体的,我们都会关爱。下面请看我们策划的第一个专题——体毛。