关键词： COVID-19   Vaccine   Heterologous booster   Third dose   Immunogenicity   Safety   OMICRON VARIANT  

摘要： Objectives: We conducted a single-blinded, randomized trial to evaluate the safety, reactogenicity, and immu-nogenicity of heterologous booster vaccination in health care workers (HCW) who had received two doses of ChAdOx1 nCov-19. Methods: HCW who had at least 90 days after the second dose were enrolled to receive one of the four vaccines: BNT162b2 (30 mu g), half-dose mRNA-1273 (50 mu g), mRNA-1273 (100 mu g), and MVC-COV1901 (15 mu g). The primary outcomes were humoral and cellular immunogenicity and secondary outcomes assessed safety and reactogenicity at 28 days post-booster. Results: MVC-COV1901 Three hundred and forty HCW were enrolled: 83 received BNT162b2 (2 excluded), 85 half-dose mRNA-1273, 85 mRNA-1273, and 85 MVC-COV1901. mRNA vaccines had more reactogenicity than protein vaccine. The fold-rise of anti-spike IgG geometric mean titer was 8.4 (95% CI 6.8-10.4) for MVC-COV1901, 32.2 (27.2-38.1) for BNT162b2, 47.6 (40.8-55.6) for half-dose mRNA-1273 and 63.2 (53.6-74.6) for mRNA-1273. The live virus microneutralization assays (LVMNA) against the wild type, alpha and delta variants were consistent with anti-spike IgG for all booster vaccines. The LVMNA in the four groups against omicron BA.1 variant were 6.4 to 13.5 times lower than those against the wild type. All booster vaccines induced a comparable T cell response. Conclusions: Third dose booster not only increases neutralizing antibody titer but also enhances antibody breadth against SARS-CoV-2 variants. mRNA vaccines are preferred booster vaccines for those who received primary series of ChAdOx1 nCov-19.

关键词： Mpro of nCoV   Molecular dynamics simulations   Molecular docking   ADME properties   Repurposing drugs   GASTROINTESTINAL TRANSIT   DRUG DISCOVERY   FORCE-FIELD   PREDICTION   COVID-19   DESIGN   PATHOPHYSIOLOGY   BIOAVAILABILITY   MECHANISMS   EXPRESSION  

摘要： The new corona virus (nCoV) is aetiological agent responsible for the viral pneumonia epidemic. Three is no specific therapeutic medicines available for the treatment of this condition and also effective treatment choices are few. In this work, authors tried to investigate few potential of repurposing drugs (5- fluorouracil, doxorubicin, methotrexate and paclitaxel) against the main protease (Mpro) of nCoV by the computational tools. Molecular docking was performed to screen out the best compound and doxorubicin was found to have minimum binding energy -121.89 kcal/mol. To further study, molecular dynamics (MD) simulations were performed at 300 K and the result successfully corroborate the energy obtained by molecular docking. Further, temperature dependent MD simulations of the best molecule, that is, doxorubicin based on results of docking, was performed to check the variation in structural changes in Mpro of nCoV at 290 K, 310 K, 320 K and 325 K. It is found that doxorubicin binds effectively with Mpro of nCoV at 290 K. Further, ADME properties of the 5- fluorouracil, doxorubicin, methotrexate and paclitaxel were also evaluated to understand the bioavailability.

关键词： 2019-nCoV   SARS-CoV-2   Novel coronavirus   Athlete(s)   Sleep health   SATED  

摘要： The COVID-19 outbreak presents a serious health challenges, with Australia enforcing tight restrictions, impacting sporting activities and sleep health of many Australians. Routine lifestyle patterns (physical activity and employment) are important to maintaining overall sleep health. Current literature indicates COVID-19 pandemic negatively affected the employment status and sport engagement. The aim of this study was to explore the effect of physical activity during COVID-19 on sleep health, and its association with employment and sport engagement of community-level athletes throughout Australia. Participants self-reported sleep health prior to COVID-19 (pre-sleep) and over the month prior to data collection (during-sleep) using the validated 5-item Satisfaction Alertness Timing Efficiency and Duration questionnaire (SATED). Wilcoxon Signed Rank Test assessed the difference in pre- and during perceived sleep health scores. A generalized linear model was used to assess the impact of sporting and demographic factors on a community athlete's change in perceived sleep health score. A total of 139 community-level Australian athletes responded. The majority of participants were aged 18-30 and engaged in full-time employment prior to COVID-19 (n = 82, 54%). Eight percent of participants were unemployed prior to the COVID-19 pandemic (n = 12, 8%). Our findings show that sleep health values were higher during COVID-19, with 91.4% of respondents able to maintain some form of physical activity during the pandemic. Together, our results show better sleep health scores reported by the respondents who maintained or lost employment and maintained sporting engagements during the pandemic.

关键词： SITR 2019-nCOV Model   Caputo Derivative   Atangana-Baleanu Derivative   Existence and Uniqueness   Numerical Simulations   DYNAMICS   DISEASE   POWER  

摘要： Currently, the entire planet is suffering from a contagious epidemic infection, 2019-nCOV due to newly detected coronavirus. This is a lethal infectious virus that has destroyed thousands of lives all over the world. The important aim of this study is to investigate a susceptible-infected-treatment-recovered (SITR) model of coronavirus (2019-nCOV) with bi-modal virus spread in a susceptible population. The considered 2019-nCOV model is analyzed by two fractional derivatives: the Caputo and Atangana-Baleanu-Caputo (ABC). For the Caputo model, we present a few basic mathematical characteristics such as existence, positivity, boundedness and stability result for disease-free equilibria. The fixed-point principle is used to establish the existence and uniqueness conditions for the ABC model solution. We employed the Adams-Bashforth-Moulton (ABM) numerical technique for the Caputo model solution and the Toufik-Atangana (TA) numerical approach for the ABC model solution. Finally, using MATLAB, the simulation results are shown to highlight the impact of arbitrarily chosen fractional-order and model parameters on infection dynamics.

关键词： 出入境旅游   新冠肺炎疫情   旅游发展   消费   经济  

摘要： 2020年初,新冠肺炎疫情暴发,对我国社会经济产生了极大的负面影响,出入境旅游由于更注重大众的体验和参与,相较于其他产业损失更为惨重.目前,无论是在出境旅游还是在入境旅游方面,相关旅游企业都受到了不小的冲击.受新冠肺炎疫情的影响,我国出入境旅游面临巨大的挑战,同时也存在机遇,尤其是后疫情时代,极有可能出现报复性的旅游消费.文章分析新冠肺炎疫情对我国出入境旅游的影响,探究后疫情时代我国出入境旅游面临的挑战与机遇,并提出相应的对策,旨在为我国出入境旅游在后疫情时代的发展提供参考和借鉴.